S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Identifieur interne : 000448 ( France/Analysis ); précédent : 000447; suivant : 000449S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Auteurs : Alexis Elbaz [France] ; Clotilde Levecque [France] ; Jacqueline Clavel [France] ; Jean-Sébastien Vidal [France] ; Florence Richard [France] ; Jean-René Corrèze [France] ; Bernard Delemotte [France] ; Philippe Amouyel [France] ; Annick Alpérovitch [France] ; Marie-Christine Chartier-Harlin [France] ; Christophe Tzourio [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Age of Onset, Age of onset, Aged, Alleles, Case control study, Case-Control Studies, Environmental Exposure (adverse effects), Female, Genetics, Genotype, Human, Humans, Insurance, Health, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pathophysiology, Pesticides (adverse effects), Polymerase chain reaction, Polymorphism, Polymorphism, Genetic (genetics), Questionnaires, Risk Factors, Smoking (adverse effects), Thiolester Hydrolases (genetics), UCH‐L1, Ubiquitin Thiolesterase, age at onset, case‐control, interaction.
- MESH :
- chemical , adverse effects : Pesticides.
- adverse effects : Environmental Exposure, Smoking.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic, Thiolester Hydrolases.
- Adolescent, Adult, Age Factors, Age of Onset, Aged, Alleles, Case-Control Studies, Female, Genotype, Humans, Insurance, Health, Male, Middle Aged, Questionnaires, Risk Factors, Ubiquitin Thiolesterase.
Abstract
We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society
Url:
- https://api.istex.fr/document/BE94855532A1663DE19AF51C8B746A2135B06CD5/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00266840
DOI: 10.1002/mds.10326
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Age of Onset</term>
<term>Age of onset</term>
<term>Aged</term>
<term>Alleles</term>
<term>Case control study</term>
<term>Case-Control Studies</term>
<term>Environmental Exposure (adverse effects)</term>
<term>Female</term>
<term>Genetics</term>
<term>Genotype</term>
<term>Human</term>
<term>Humans</term>
<term>Insurance, Health</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pathophysiology</term>
<term>Pesticides (adverse effects)</term>
<term>Polymerase chain reaction</term>
<term>Polymorphism</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Questionnaires</term>
<term>Risk Factors</term>
<term>Smoking (adverse effects)</term>
<term>Thiolester Hydrolases (genetics)</term>
<term>UCH‐L1</term>
<term>Ubiquitin Thiolesterase</term>
<term>age at onset</term>
<term>case‐control</term>
<term>interaction</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
<term>Thiolester Hydrolases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Insurance, Health</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Questionnaires</term>
<term>Risk Factors</term>
<term>Ubiquitin Thiolesterase</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Age apparition</term>
<term>Etude cas témoin</term>
<term>Gène UCH-L1</term>
<term>Génétique</term>
<term>Homme</term>
<term>Parkinson maladie</term>
<term>Physiopathologie</term>
<term>Polymorphisme</term>
<term>Réaction chaîne polymérase</term>
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<front><div type="abstract" xml:lang="en">We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</div>
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<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<name sortKey="Correze, Jean Ene" sort="Correze, Jean Ene" uniqKey="Correze J" first="Jean-René" last="Corrèze">Jean-René Corrèze</name>
<name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name>
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<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<name sortKey="Vidal, Jean Ebastien" sort="Vidal, Jean Ebastien" uniqKey="Vidal J" first="Jean-Sébastien" last="Vidal">Jean-Sébastien Vidal</name>
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